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In Vivo. 2007 Sep-Oct;21(5):877-83.

Uniform and prolonged changes in blood oxidative stress after muscle-damaging exercise.

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  • 1Department of Physical Education and Sport Science, University of Thessaly, 42100, Trikala, Greece.

Abstract

BACKGROUND:

The effect of eccentric exercise on the time-course changes in several indices of muscle damage and blood oxidative stress was examined.

MATERIALS AND METHODS:

Isometric torque, delayed-onset muscle soreness, creatine kinase, reduced glutathione (GSH), oxidized glutathione (GSSG), thiobarbituric-acid reactive substances (TBARS), protein carbonyls, catalase, uric acid, bilirubin and total antioxidant capacity (TAC) in blood were measured pre-, 24 h, 48 h and 72 h post-eccentric exercise of knee extensors in ten females.

RESULTS:

The concentration of all oxidative stress indices changed significantly in a way indicating increased oxidative stress in the blood (GSH and GSH/GSSG, decreased, whereas GSSG, TBARS, protein carbonyls, catalase, uric acid, bilirubin and TAC increased) peaking, in all but TBARS, at 48 h and returning toward baseline afterwards.

CONCLUSION:

We believe that muscle-damaging exercise should be viewed as a different challenge compared to non-muscle-damaging exercise with regard to its effects on blood oxidative stress.

PMID:
18019428
[PubMed - indexed for MEDLINE]
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