Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Ann Hepatol. 2007 Oct-Dec;6(4):208-13.

Mechanisms of angiogenesis in chronic inflammatory liver disease.

Author information

  • 1Hepatology Department and Ciberehd. University Hospital La Princesa. Universidad Autonoma de Madrid. Spain. mariachs2005@gmail.com

Abstract

Intrahepatic hypoxia may occur during the inflammatory and fibrotic processes that characterize several chronic liver diseases of viral and autoimmune origin. As a consequence, new vascular structures are formed to provide oxygen and nutrients. Angiogenesis involves a tightly regulated network of cellular and molecular mechanisms that result in the formation of functional vessels. Of particular importance are growth factors and molecules involved in matrix remodeling and cell migration, as weel as vessel maturation-related factors. In recent years a number of studies have investigated the expression and function of many pro- and antiangiogenic molecules in chronic liver diseases and liver regeneration. This review examines the potential pathogenic role of angiogenesis in the context of viral hepatitis, autoinmmune hepatitis, primary biliary cirrhosis and hepatocellular carcinoma.

PMID:
18007549
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk