Biphenyl amide p38 kinase inhibitors 1: Discovery ...[Bioorg Med Chem Lett. 2008]

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1: Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19. Links

Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode.

Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL.

GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.

The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.

PMID: 18006306 [PubMed - indexed for MEDLINE]

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Structures reported by this article

Crystal Structure Of P38 In Complex With Biphenyl Amide Inhibitor

PDB: 2ZB1

Source: Homo sapiens

Method: X-Ray Diffraction | Resolution: 2.5 Å
» See all 3 structures...

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