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    Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19.

    Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode.

    Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL.

    GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.

    The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.

    PMID: 18006306 [PubMed - indexed for MEDLINE]

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