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Cell Host Microbe. 2007 Jul 12;2(1):1-2.

ESCRT-I part II: forming the real ESCRT-I complex.

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  • 1Unit for Virus Host Cell Interaction, UMR 5233 University Joseph Fourier-EMBL-CNRS, 6 rue Jules Horowitz, 38042 Grenoble, France.


Many enveloped viruses hijack the cellular ESCRT machinery to catalyze their escape from host cells. One paper in a recent issue of Cell by Kostelansky et al. and another in this issue of Cell Host & Microbe by Morita et al. shed new light on the structure and function of ESCRT-I. Both papers focus on a fourth ESCRT-I component that shapes ESCRT-I into an elongated structure and affects HIV-1 morphogenesis.

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