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Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19671-8. Epub 2007 Nov 14.

The process of mRNA-tRNA translocation.

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  • 1Howard Hughes Medical Institute and Health Research Incorporated, Wadsworth Center, Empire State Plaza, Albany, NY 12201-0509, USA. joachim@wadsworth.org


In the elongation cycle of translation, translocation is the process that advances the mRNA-tRNA moiety on the ribosome, to allow the next codon to move into the decoding center. New results obtained by cryoelectron microscopy, interpreted in the light of x-ray structures and kinetic data, allow us to develop a model of the molecular events during translocation.

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