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Differential optical spectroscopy for absorption characterization of mono & two-layered scattering media.

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  • 1CREATIS-LRMN, CNRS UMR 5220, Universit√© de Lyon, France. Cyril.Billet@univ-lyon1.fr

Abstract

Diffuse reflectance techniques are commonly used to characterize the optical properties of various biological tissues in the visible and NIR spectral ranges. Nevertheless a sharp determination of local chromophores concentration in turbid media is usually difficult to obtain because of the nonlinear dependence of the reflected light intensity as a function of scattering and absorption coefficients. The proposed technique of this paper allows to determine absorbent compounds concentration ratios in a turbid medium from three reflectance spectra, measured for source-detector distances inferior to 1 cm. This method is validated in the visible range in case of typical biological absorption and reduced scattering coefficients. Two-layered scattering media are also investigated.

PMID:
18002533
[PubMed - indexed for MEDLINE]
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