(A) Four different strains, both males (M) and females (F) of 8–9 wk, were examined. For the results of analysis of variance, see Table S1. The comparison of male and female groups in each strain and each prepulse level did not show any significant difference by Student t-test.
(B) Male B6 and C3 mice at 7 wk and 12 wk were examined.

The results from the dense mapping of chromosomes in females that harbor significant QTLs detected in the second scan are shown. The chromosomes with lod scores not exceeding the threshold are eliminated. The positions of markers used in the first scan are indicated by black triangles, and those added in the second stage scan (‘dense') by red triangles. Analysis was performed using the MIM method. M1, rs33089794; M2, Cdh23 SNP; M3, Ofcc1 SNP; M4, Dtnbp1 SNP.

(A and B) In the hippocampal dentate gyrus at 4 wk, Fabp7-null mice show decreased expression of GFAP (a neural stem/early progenitor marker) and PSA-NCAM (a late progenitor marker).
(C and D) The number of BrdU-incorporated cells is markedly reduced in Fabp7-null mice at 4 wk, suggesting a dramatic decrease in the production of new neurons.

The results from the dense mapping of chromosomes in males that harbor significant QTLs detected in the second scan are shown. The chromosomes with lod scores not exceeding the threshold are eliminated. The positions of markers used in the first scan are indicated by black triangles, and those added in the second stage scan (‘dense') by red triangles. Analysis was performed using the MIM method. M1, rs33089794, the nearest verified SNP to Fabp7; M2, Cdh23 SNP; M3, Ofcc1 SNP; M4, Dtnbp1 SNP.

(A) Relative expression levels of Fabp7 at different developmental stages and anatomical regions in B6 and C3 mice. The adult stage mice were all males. CX, cerebral cortex; HP, hippocampus; CE, cerebellum; FC, frontal cortex; OB, olfactory bulb, *p < 0.05
(B) PPI (%) between wild-type (WT, n = 9: six males and three females) and Fabp7 (–/–) mice (KO, n = 12: six males and six females). The values represent mean ± s.e. *p < 0.05.
(C) Latency between male wild-type (WT, n = 9: six males and three females) and Fabp7 (–/–) mice (KO, n = 12: six males and six females). The values represent mean ± s.e. *p < 0.05.
(D) Locomotor responses after a single injection of MK-801 in male wild-type (WT, n = 6) and Fabp7 (–/–) mice (KO, n = 6).
(E) Locomotor responses after a challenge injection of MK-801, following five repeated pre-treatments, in male wild-type (WT, n = 6) and Fabp7 (–/–) mice (KO, n = 6). The genotype effect was significant [F(1,5) = 5.18, p < 0.05]. *p < 0.05 after post hoc analysis.

(A) Relative mRNA levels of FABP7 in the BA 46 region of control and schizophrenic postmortem brains.
(B) Genomic structure and location of polymorphic sites in FABP7. Exons are denoted by boxes, with untranslated regions in white and translated regions in black. The sizes of exons and introns are also shown. “rs” is an NCBI I.D. nomenclature (http://www.ncbi.nlm.nih.gov/) and ”hCV” is derived from the Celera Discovery System (https://www.appliedbiosystems.com/).
(C) The haplotype block pattern of the FABP7 interval is shown. The number in each cell represents the linkage disequilibrium parameter D' (×100), red cells mean D' = 1. Each cell color is graduated relative to the strength of linkage disequilibrium between markers, which is defined by both the D' value and confidence bounds on D'. Note that the FABP7 region consists of two haplotype blocks.
(D) Allelic p-values for single-locus and global p-values from multilocus (two, three, and block 1) association analysis. Minor allele frequency data in control samples for individual SNPs were as follows: SNP1 (C = 0.09), SNP2 (A = 0.34), SNP3 (G = 0.36), SNP4 (T = 0.03), SNP5 (G = 0.38), SNP6 (T = 0.24), SNP7 (C = 0.10), and SNP8 (C = 0.36).
(E) The site of the missense polymorphism (SNP4), Thr61Met in the FABP7 structure. The methionine residue (white) overlaps with Thr61 (magenta) of the crystal structure with DHA (yellow) (PDB ID: 1FDQ) [52]. The side-chain rotamer of methionine is arbitrary. A hydrogen bond between Thr61 and a water molecule is shown as a blue dashed line. The graphic was created using PyMOL (DeLano Scientific).