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Nano Lett. 2007 Dec;7(12):3818-21. Epub 2007 Nov 13.

Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles.

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  • 1Department of Chemistry and International Institute for Nanotechnology, Northwestern University, Evanston, IL 60208-3113, USA.


The cellular internalization of oligonucleotide-modified nanoparticles is investigated. Uptake is dependent on the density of the oligonucleotide loading on the surface of the particles, where higher densities lead to greater uptake. Densely functionalized nanoparticles adsorb a large number of proteins on the nanoparticle surface. Nanoparticle uptake is greatest where a large number of proteins are associated with the particle.

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