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Mol Cell. 2007 Nov 9;28(3):354-6.

AROuSing SIRT1: identification of a novel endogenous SIRT1 activator.

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  • 1Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, CA 94158, USA. everdin@gladstone.ucsf.edu

Abstract

SIRT1 is a protein deacetylase that regulates cellular responses to a variety of stresses. In a recent issue of Molecular Cell, Kim et al. (2007) report the identification of a cellular protein, AROS, that activates the SIRT1-mediated deacetylation of p53.

PMID:
17996699
[PubMed - indexed for MEDLINE]
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