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Nat Neurosci. 2007 Dec;10(12):1513-4. Epub 2007 Nov 11.

Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA.

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  • 1Vollum Institute, Oregon Health & Science University, Portland, Oregon 97239, USA.


Both increases and decreases in methyl CpG-binding protein 2 (MeCP2) levels cause neurodevelopmental defects. We found that MeCP2 translation is regulated by microRNA 132 (miR132). Block of miR132-mediated repression increased MeCP2 and brain-derived neurotrophic factor (BDNF) levels in cultured rat neurons and the loss of MeCP2 reduced BDNF and miR132 levels in vivo. This feedback loop may provide a mechanism for homeostatic control of MeCP2 expression.

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