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Menopause. 2008 Mar-Apr;15(2):388-92.

Endocrine regulation of the course of menopause by oral melatonin: first case report.

Author information

  • 1Departamento de Biologia Funcional, Universidad de Oviedo, Oviedo, Spain. beatrizd@uniovi.es

Abstract

OBJECTIVE:

The pineal gland, through its hormone melatonin, is involved in the mechanisms that regulate the aging process involved in the onset of menopause. Considering the melatonin changes reported during pre-, peri-, and postmenopause, an influence of melatonin on the hormonal changes associated with menopause transition could be expected.

DESIGN:

We report the first longitudinal case study, covering a 7.5-year period, on the effects of melatonin administration on the reproductive hormones luteinizing hormone, follicle-stimulating hormone, and 17[beta]-estradiol during that period of the reproductive life.

RESULTS AND CONCLUSION:

The data obtained in this case report show that melatonin administration was able to delay the characteristic endocrine changes that occur during the course of menopause.

PMID:
17993994
[PubMed - indexed for MEDLINE]
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