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1: J Bacteriol. 2008 Jan;190(2):755-8. Epub 2007 Nov 9.Click here to read Click here to read Links

DNA polymerase I is not required for replication of linear chromosomes in streptomyces.

Huang TW, Chen CW.

Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Shih-Pai, Taipei 112, Taiwan.

Both polA (encoding DNA polymerase I; Pol I) and a paralog were deleted from Streptomyces strains. Despite the UV sensitivity and slow growth caused by the DeltapolA mutation, the double mutant was viable. Thus, in contrast to a previous postulate, Pol I and its paralog are not essential for replication of Streptomyces chromosomes.

PMID: 17993519 [PubMed - indexed for MEDLINE]

PMCID: PMC2223709