Format

Send to:

Choose Destination
See comment in PubMed Commons below
Trends Microbiol. 2007 Nov;15(11):508-15. Epub 2007 Nov 7.

New insight into the molecular mechanisms of two-partner secretion.

Author information

  • 1Department of Molecular, Cellular and Developmental Biology, University of California-Santa Barbara, Santa Barbara, CA 93106-9610, USA.

Abstract

Two-partner secretion (TPS) systems, which export large proteins to the surface and/or extracellular milieu of Gram-negative bacteria, are members of a large superfamily of protein translocation systems that are widely distributed in animals, plants and fungi, in addition to nearly all groups of Gram-negative bacteria. Recent intense research on TPS systems has provided new insight into the structure and topology of the outer membrane translocator proteins and the large exoproteins that they secrete, the interactions between them, and mechanisms for retention of some of the secreted proteins on the bacterial surface. Evidence for secretion-dependent folding of mature exoproteins has also been obtained. Together, these findings provide a deeper understanding of the molecular mechanisms underlying these simple but elegant secretion systems.

PMID:
17988872
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk