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    J Neurol Sci. 2008 Apr 15;267(1-2):174-6. Epub 2007 Nov 7.

    Antioxidant use in Friedreich ataxia.

    Source

    Department of Neurology, University of Pennsylvania School of Medicine, USA.

    Abstract

    Many antioxidants have been suggested as potential treatments for Friedreich ataxia, but have not been tested in clinical trials. We found that a majority of patients in our cohort already use such antioxidants, including idebenone, which is not available at a pharmaceutical grade in the United States. Younger age, cardiomyopathy and shorter GAA repeat length were independent predictors of idebenone use, but no factors predicted use of other antioxidants. This confirms that non-prescription antioxidant use represents a major confounder to formal trials of existing and novel agents for Friedreich ataxia.

    PMID:
    17988688
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2279016
    Free PMC Article

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