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Nat Rev Mol Cell Biol. 2008 Jan;9(1):72-81.

Regulation of iron acquisition and storage: consequences for iron-linked disorders.

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  • 1Department of Pathology, School of Medicine, University of Utah, Salt Lake City, Utah 84132, USA.


Mammalian iron homeostasis must be meticulously regulated so that this essential element is available for use, but at the same time prevented from promoting the formation of toxic radicals. Controlling the entry of iron into blood plasma is the main mechanism by which iron stores in the body are physiologically manipulated and regulated. Defects in iron acquisition at the cellular and systemic levels lead to human disorders, which involve either iron overload or iron deficiency. Discoveries of iron transporters and insights into their regulation have provided important information about iron metabolism and genetic iron disorders.

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