Bioorg Med Chem. 2008 Jan 15;16(2):874-80. Epub 2007 Oct 22.

Design, synthesis and structure-activity study of shorter hexa peptide analogues as HIV-1 protease inhibitors.

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Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, Karnataka, India.

Abstract

Inhibition of HIV-1 protease enzyme can render the Human Immunodeficiency Virus (HIV-1) non-infectious in vitro. Previous studies have shown that several shorter peptides were discovered as HIV-1 protease inhibitors. In this context, a series of shorter synthetic hexapeptides, Leu-Leu-Glu-Tyr-Val-Xaa (Xaa=Phe, Met, Tyr and Trp), were designed. The synthesized hexa peptides were screened for their HIV-1 protease inhibition. These peptides showed moderately good HIV-1 protease inhibition when compared to acetyl pepstatin.

PMID:: 17981043; [PubMed - indexed for MEDLINE]

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Design, synthesis and structure-activity study of shorter hexa peptide analogues as HIV-1 protease inhibitors.

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