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Biochem Biophys Res Commun. 2008 Jan 4;365(1):35-41. Epub 2007 Nov 1.

CD24 induces localization of beta1 integrin to lipid raft domains.

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  • 1Tumor Immunology Programme, D010, German Cancer Research Center, Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany.

Abstract

The expression of the glycosyl phosphatidylinositol (GPI)-anchored protein CD24 correlates with poor prognosis in a variety of carcinomas. However, little is known about the cellular mechanisms of the CD24-mediated effects. In this study, we present evidence that CD24 affects the lateral localization of beta1 integrin. Using stably CD24-transfected A125 and MDA-MB-435S carcinoma cells we show that CD24 augments beta1-dependent cell motility and stimulates transmigration and invasion across a monolayer of endothelial cells. Furthermore, as demonstrated by sucrose density gradient centrifugation and Western Blot analysis, CD24 recruits beta1 integrin into lipid raft domains. We suggest that CD24 acts as a gate-keeper for lipid rafts, thereby regulating the activity of integrins and other proteins.

PMID:
17980703
[PubMed - indexed for MEDLINE]
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