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Bioorg Med Chem Lett. 2007 Dec 15;17(24):6797-800. Epub 2007 Oct 17.

Syntheses of novel myxopyronin B analogs as potential inhibitors of bacterial RNA polymerase.

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  • 1Anadys Pharmaceuticals, Inc., 3115 Merryfield Row, San Diego, CA 92121, USA.

Abstract

Based upon observations from our initial findings, additional myxopyronin B analogs have been prepared and tested for in vitro inhibitory activity against DNA-dependent RNA polymerase and antibacterial activity against Escherichia coli and Staphylococcus aureus.

PMID:
17980587
[PubMed - indexed for MEDLINE]
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