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Respir Med. 2008 Feb;102(2):313-5. Epub 2007 Nov 5.

Use of the QuantiFERON-TB Gold test in Japanese patients with sarcoidosis.

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  • 1The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan. inui@hama-med.ac.jp

Abstract

BACKGROUND AND OBJECTIVE:

Mycobacterium tuberculosis has been proposed as a candidate agent for the cause of sarcoidosis. The QuantiFERON-TB Gold test has a higher specificity for detecting M. tuberculosis infection than the conventional tuberculin skin test. This study aimed to investigate the rate of positive QuantiFERON-TB Gold results in Japanese sarcoidosis patients.

PATIENTS AND METHODS:

The QuantiFERON-TB Gold test, an enzyme-linked immunosorbent assay, was used to assess the levels of interferon-gamma resulting from immune responses to M. tuberculosis-specific antigens, namely early secretory antigen target 6 and culture filtrate protein 10, in 90 Japanese sarcoidosis patients.

RESULTS:

The QuantiFERON-TB Gold result was positive in 3 of the 90 patients tested.

CONCLUSION:

The positivity rate of QuantiFERON-TB Gold was 3.3% in Japanese sarcoidosis patients.

PMID:
17980570
[PubMed - indexed for MEDLINE]
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