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Head Neck. 2008 Jun;30(6):810-4.

Response to paclitaxel in adenoid cystic carcinoma of the salivary glands.

Author information

  • 1Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., D3-190, Seattle, Washington 98109, USA. tillb@fhcrc.org

Abstract

BACKGROUND:

Paclitaxel is not considered to be an active drug in adenoid cystic carcinoma (ACC) of the salivary glands. We report 2 consecutive cases of patients with ACC who responded to paclitaxel.

METHODS:

The patients were: (1) a 58-year-old man with recurrent ACC who developed pulmonary metastases, had progressive disease after a good response to first-line chemotherapy, and then achieved a partial response to weekly single- agent paclitaxel; and (2) a 46-year-old woman with extensive thoracic ACC metastases who achieved a significant response after 2 cycles of paclitaxel chemotherapy.

RESULTS:

The first patient died of progressive disease approximately 4 months after completing paclitaxel therapy, and the second patient had disease control after 6 cycles of paclitaxel.

CONCLUSIONS:

Systemic weekly paclitaxel produced a significant response in 2 patients with ACC of the head and neck, and its use in this disease merits further study.

PMID:
17979110
[PubMed - indexed for MEDLINE]
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