Diabetes Care. 2008 Feb;31(2):361-2. Epub 2007 Oct 31.

High serum uric acid as a novel risk factor for type 2 diabetes.

Dehghan A, van Hoek M, Sijbrands EJ, Hofman A, Witteman JC.

Source

Epidemiology & Biostatistics, Erasmus Medical Center, Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, Netherlands.

Abstract

OBJECTIVE:

To investigate the association between serum uric acid level and risk of type 2 diabetes.

RESEARCH DESIGN AND METHODS:

The population for analysis consisted of 4,536 subjects free from diabetes at baseline. During a mean of 10.1 years of follow-up, 462 subjects developed diabetes.

RESULTS:

The age- and sex-adjusted hazard ratios (HRs) (95% CIs) for diabetes were 1.30 (0.96-1.76) for the second, 1.63 (1.21-2.19) for the third, and 2.83 (2.13-3.76) for the fourth quartile of serum uric acid, in comparison with the first quartile. After adjustment for BMI, waist circumference, systolic and diastolic blood pressure, and HDL cholesterol, the HRs decreased to 1.08 (0.78-1.49), 1.12 (0.81-1.53), and 1.68 (1.22-2.30), respectively.

CONCLUSIONS:

The results of this population-based study suggest that serum uric acid is a strong and independent risk factor for diabetes.

Comment in

Uric acid indicates a high cardiovascular risk profile but is not closely associated with insulin resistance in obese adolescents. [Diabetes Care. 2008]
Uric acid indicates a high cardiovascular risk profile but is not closely associated with insulin resistance in obese adolescents.Mangge H, Pilz S, Haj-Yahya S, Almer G. Diabetes Care. 2008 Apr; 31(4):e21.
High serum uric acid as a novel risk factor for type 2 diabetes: response to Dehghan et al. [Diabetes Care. 2008]
High serum uric acid as a novel risk factor for type 2 diabetes: response to Dehghan et al.Dai CY, Chuang WL, Ho CK, Ou TT, Huang JF, Hsieh MY, Yu ML. Diabetes Care. 2008 Sep; 31(9):e67.
High serum uric acid as a novel risk factor for type 2 diabetes: response to Dehghan et al. [Diabetes Care. 2008]
High serum uric acid as a novel risk factor for type 2 diabetes: response to Dehghan et al.Lippi G, Targher G, Montagnana M, Salvagno GL, Guidi GC. Diabetes Care. 2008 Sep; 31(9):e68.

PMID:: 17977935; [PubMed - indexed for MEDLINE]

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Uric Acid

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