Display Settings:

Format

Send to:

Choose Destination
Eye Contact Lens. 2007 Nov;33(6 Pt 2):394-8; discussion 399-400.

The role of contact lens type, oxygen transmission, and care-related solutions in mediating epithelial homeostasis and pseudomonas binding to corneal cells: an overview.

Author information

  • 1Department of Ophthalmology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9057, USA.

Abstract

Despite the widespread acceptance of silicone hydrogel contact lenses, microbial keratitis remains the most significant complication associated with contact lens wear and Pseudomonas aeruginosa is still recognized as the leading causative organism. The purpose of this review is to summarize and update the current knowledge of the effects of lens type, oxygen transmissibility, wearing mode, and contact-lens care solutions on corneal epithelial biology and lens-induced P. aeruginosa binding from human and animal studies. The collective results of this work suggest that there is a net interactive effect on corneal epithelial cells among these risk factors. Significantly, hyper-oxygen-transmissible lenses in any wearing mode with non-preserved care solutions appear to offer the safest potential clinical choice for contact lens wear.

PMID:
17975430
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk