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Dement Geriatr Cogn Disord. 2007;24(6):448-56. Epub 2007 Nov 1.

Vascular risk factors in mild cognitive impairment subtypes. Findings from the ReGAl project.

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  • 1Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.

Abstract

BACKGROUND AND AIM:

To investigate the role of vascular risk factors in different subtypes of mild cognitive impairment (MCI) in a multicentric, clinic-based, cross-sectional study.

METHODS:

Two-hundred and seven subjects with MCI were included in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a) and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesions were evaluated.

RESULTS:

snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, a higher Hachinski ischaemic score and a higher frequency of white-matter lesions on MRI compared to aMCI. Subjects with mdMCI-a showed clinical characteristics similar to aMCI, except for a higher frequency of a history of TIA/stroke.

CONCLUSION:

Our findings suggest that snmMCI may be considered a vascular cognitive disorder.

(c) 2007 S. Karger AG, Basel.

PMID:
17975314
[PubMed - indexed for MEDLINE]
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