Format

Send to:

Choose Destination
See comment in PubMed Commons below
BMJ. 2007 Nov 10;335(7627):974. Epub 2007 Nov 1.

Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis.

Author information

  • 1Imperial College School of Medicine, London.

Abstract

OBJECTIVE:

To quantify the risk of future cardiovascular diseases, cancer, and mortality after pre-eclampsia.

DESIGN:

Systematic review and meta-analysis.

DATA SOURCES:

Embase and Medline without language restrictions, including papers published between 1960 and December 2006, and hand searching of reference lists of relevant articles and reviews for additional reports.

REVIEW METHODS:

Prospective and retrospective cohort studies were included, providing a dataset of 3,488,160 women, with 198,252 affected by pre-eclampsia (exposure group) and 29,495 episodes of cardiovascular disease and cancer (study outcomes).

RESULTS:

After pre-eclampsia women have an increased risk of vascular disease. The relative risks (95% confidence intervals) for hypertension were 3.70 (2.70 to 5.05) after 14.1 years weighted mean follow-up, for ischaemic heart disease 2.16 (1.86 to 2.52) after 11.7 years, for stroke 1.81 (1.45 to 2.27) after 10.4 years, and for venous thromboembolism 1.79 (1.37 to 2.33) after 4.7 years. No increase in risk of any cancer was found (0.96, 0.73 to 1.27), including breast cancer (1.04, 0.78 to 1.39) 17 years after pre-eclampsia. Overall mortality after pre-eclampsia was increased: 1.49 (1.05 to 2.14) after 14.5 years.

CONCLUSIONS:

A history of pre-eclampsia should be considered when evaluating risk of cardiovascular disease in women. This association might reflect a common cause for pre-eclampsia and cardiovascular disease, or an effect of pre-eclampsia on disease development, or both. No association was found between pre-eclampsia and future cancer.

PMID:
17975258
[PubMed - indexed for MEDLINE]
PMCID:
PMC2072042
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk