Mamm Genome. 1991;1(3):130-44.

Molecular mapping of obesity genes.

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Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021.

Abstract

Advances in molecular genetics have made it possible to clone mutant genes from mammals. This capability should facilitate efforts to determine the genetic factors that control food intake and body composition. In order to identify these genetic factors, we have been making use of mouse mutations that cause obesity. The basic premise of this approach is to take advantage of the mouse as a genetic system for the analysis of genetically complex disorders and to then apply that information to the study of human disease. This paper reviews: (1) current concepts concerning the control of body weight in man and other mammals; (2) the biologic characteristics of the mouse obesity mutations; (3) our progress in the use of positional cloning techniques to clone the mouse obese (ob) and diabetes (db) genes; (4) an approach to polygenic obesity in mice; and (5) the possible relevance of the mouse obesity mutations to human obesity.

PMID:: 1797227; [PubMed - indexed for MEDLINE]

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Review Strategies for the molecular genetic analysis of obesity in humans. [Crit Rev Food Sci Nutr. 1993]
Review Strategies for the molecular genetic analysis of obesity in humans.
Leibel RL, Bahary N, Friedman JM. Crit Rev Food Sci Nutr. 1993; 33(4-5):351-8.
Positional cloning of the mouse obese gene and its human homologue. [Nature. 1994]
Positional cloning of the mouse obese gene and its human homologue.
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Nature. 1994 Dec 1; 372(6505):425-32.
Reduction of food intake and weight gain by the ob protein requires a specific secondary structure and is reversible. [Mol Med. 1996]
Reduction of food intake and weight gain by the ob protein requires a specific secondary structure and is reversible.
Giese K, Fantl WJ, Vitt C, Stephans JC, Cousens L, Wachowicz M, Williams LT. Mol Med. 1996 Jan; 2(1):50-8.
[Cloning of the ob gene, a decisive advance in genetics of obesity in the mouse and in man]. [Rev Med Interne. 1995]
[Cloning of the ob gene, a decisive advance in genetics of obesity in the mouse and in man].
Thomas M. Rev Med Interne. 1995; 16(8):587-8.
Review Using mouse models to dissect the genetics of obesity. [Trends Genet. 2002]
Review Using mouse models to dissect the genetics of obesity.
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Cited by 4 PubMed Central articles

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Molecular mapping of obesity genes.

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