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Nat Rev Mol Cell Biol. 2007 Dec;8(12):1018-24.

Cell evolution and the problem of membrane topology.

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  • 1European Molecular Biology Laboratory, Heidelberg, Germany. gareth.griffiths@embl-heidelberg.de

Abstract

Cells somehow evolved from primordial chemistry and their emergence depended on the co-evolution of the cytoplasm, a genetic system and the cell membrane. It is widely believed that the cytoplasm evolved inside a primordial lipid vesicle, but here I argue that the earliest cytoplasm could have co-evolved to high complexity outside a vesicle on the membrane surface. An invagination of the membrane, aided by an early cytoskeletal system, may have formed the first cells--initially within primordial vesicles.

PMID:
17971839
[PubMed - indexed for MEDLINE]
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