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Nat Rev Drug Discov. 2007 Nov;6(11):904-16.

Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges.

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  • 1Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226, USA.

Erratum in

  • Nat Rev Drug Discov. 2008 Feb;7(2):185.

Abstract

Serious adverse drug reactions (SADRs) are a major cause of morbidity and mortality worldwide. Some SADRs may be predictable, based upon a drug's pharmacodynamic and pharmacokinetic properties. Many, however, appear to be idiosyncratic. Genetic factors may underlie susceptibility to SADRs and the identification of predisposing genotypes may improve patient management through the prospective selection of appropriate candidates. Here we discuss three specific SADRs with an emphasis on genetic risk factors. These SADRs, selected based on wide-sweeping clinical interest, are drug-induced liver injury, statin-induced myotoxicity and drug-induced long QT and torsades de pointes. Key challenges for the discovery of predictive risk alleles for these SADRs are also considered.

PMID:
17971785
[PubMed - indexed for MEDLINE]
PMCID:
PMC2763923
Free PMC Article
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