Format

Send to:

Choose Destination
See comment in PubMed Commons below
Br J Cancer. 2008 Jan 29;98(2):256-62. Epub 2007 Oct 30.

Nf2/Merlin: a coordinator of receptor signalling and intercellular contact.

Author information

  • 1Massachusetts General Hospital Center for Cancer Research, Department of Pathology, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.

Abstract

This review explores possible mechanisms by which the neurofibromatosis type-2 tumour suppressor Merlin regulates contact-dependent inhibition of proliferation. Starting from an evolutionary perspective, the concurrent emergence of intercellular contacts and proliferation control in multicellular organisms is first considered. Following a brief survey of the molecular and subcellular milieus in which merlin performs its function, the importance of different cellular and biological contexts in defining the function of merlin is discussed. Finally, an integrated model for merlin and the Ezrin, Radixin, and Moesin (ERM) proteins functioning in the regulation of cellular interfaces is proposed.

PMID:
17971776
[PubMed - indexed for MEDLINE]
PMCID:
PMC2361439
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Write to the Help Desk