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Nat Rev Genet. 2008 Jan;9(1):9-14.

New links to the pathogenesis of Crohn disease provided by genome-wide association scans.

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  • Division of Genetics and Molecular Medicine, King's College London School of Medicine, 8th Floor Guy's Tower, Guy's Hospital, London SE1 9RT, UK. christopher.mathew@Genetics.kcl.ac.uk


Genome-wide association scans (GWAS) using large case-control samples and several hundred thousand genetic markers have uncovered at least ten new genomic regions associated with susceptibility to Crohn disease, a chronic inflammatory bowel disorder. The new loci include genes with diverse roles in the immune response and several gene deserts, which may contain regulatory sequences or encode novel functional transcripts. The results so far suggest that genome scans may re-define our ideas on the nature of causal variants in complex disease.

[PubMed - indexed for MEDLINE]
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