Rev Med Virol. 2008 Jan-Feb;18(1):19-34.

Antiviral treatment of chronic hepatitis B virus infections: the past, the present and the future.

Férir G, Kaptein S, Neyts J, De Clercq E.

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Rega Institute for Medical Research, KULeuven, Leuven, Belgium.

Abstract

A decade ago, standard therapy against chronic hepatitis B virus infections only consisted of lamivudine or IFN-alpha. Treatment with lamivudine and IFN has been compounded by, respectively, the emergence of drug-resistant virus strains and the appearance of serious side effects. In the last 10 years, hepatitis B treatment has made much progress. Several treatments are now licensed for the treatment of patients with chronic hepatitis B and others are under development. Here, we provide an overview of the potential and mode of action of anti-HBV agents that are currently available, and/or may become available in the near future. Foremost among these newer compounds are adefovir dipivoxil, entecavir and telbivudine.

John Wiley & Sons, Ltd

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