Crossover interference underlies sex differences i...[Trends Genet. 2007]

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1: Trends Genet. 2007 Nov;23(11):539-42. Epub 2007 Oct 26. Links

Crossover interference underlies sex differences in recombination rates.

Petkov PM, Broman KW, Szatkiewicz JP, Paigen K.

Center for Genome Dynamics, The Jackson Laboratory, Bar Harbor, ME 04609, USA. Petko.Petkov@jax.org

In many organisms, recombination rates differ between the two sexes. Here we show that in mice, this is because of a shorter genomic interference distance in females than in males, measured in Mb. However, the interference distance is the same in terms of bivalent length. We propose a model in which the interference distance in the two sexes reflects the compaction of chromosomes at the pachytene stage of meiosis.

PMID: 17964681 [PubMed - indexed for MEDLINE]

Inter-sex variation in synaptonemal complex lengths largely determine the different recombination rates in male and female germ cells. [Cytogenet Genome Res. 2004]
High rate of recombination and double crossovers in the mouse pseudoautosomal region during male meiosis. [Proc Natl Acad Sci U S A. 1987]
Recombination, interference and sequence: comparison of chromosomes 21 and 22. [Ann Hum Genet. 2002]
Ultrastructural analysis of meiotic recombination and chiasma formation. [Tokai J Exp Clin Med. 1986]
Detection of genetic interference: simulation studies and mouse data. [Genetics. 1994]
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Crossover interference underlies sex differences in recombination rates.

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