Trends Genet. 2007 Nov;23(11):539-42. Epub 2007 Oct 26.

Crossover interference underlies sex differences in recombination rates.

Petkov PM, Broman KW, Szatkiewicz JP, Paigen K.

Source

Center for Genome Dynamics, The Jackson Laboratory, Bar Harbor, ME 04609, USA. Petko.Petkov@jax.org

Abstract

In many organisms, recombination rates differ between the two sexes. Here we show that in mice, this is because of a shorter genomic interference distance in females than in males, measured in Mb. However, the interference distance is the same in terms of bivalent length. We propose a model in which the interference distance in the two sexes reflects the compaction of chromosomes at the pachytene stage of meiosis.

PMID:: 17964681; [PubMed - indexed for MEDLINE]

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Crossover interference underlies sex differences in recombination rates.

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Cited by 13 PubMed Central articles

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