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1: Mol Cell. 2007 Oct 26;28(2):184-6.Click here to read Links

Achieving broad substrate specificity in damage recognition by binding accessible nondamaged DNA.

Schärer OD.

Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11974-3400, USA. orlando@pharm.stonybrook.edu

The structure of the Rad4/Rad23 protein, shown in a recent issue of Nature (Min and Pavletich, 2007), reveals how structurally diverse lesions are recognized in eukaryotic nucleotide excision repair: by probing for accessible nondamaged DNA opposite the lesion.

PMID: 17964258 [PubMed - indexed for MEDLINE]