Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11974-3400, USA. orlando@pharm.stonybrook.edu
The structure of the Rad4/Rad23 protein, shown in a recent issue of Nature (Min and Pavletich, 2007), reveals how structurally diverse lesions are recognized in eukaryotic nucleotide excision repair: by probing for accessible nondamaged DNA opposite the lesion.