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Ubiquitination and degradation of Tal1/SCL are induced by notch signaling and depend on Skp2 and CHIP.
Nie L, Wu H, Sun XH.
J Biol Chem. 2008 Jan 11;283(2):684-92. Epub 2007 Oct 25.
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Phosphorylation by mitogen-activated protein kinase mediates the hypoxia-induced turnover of the TAL1/SCL transcription factor in endothelial cells.
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