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Ann Clin Biochem. 2007 Nov;44(Pt 6):512-5.

Serum free light chains; the need to establish local reference intervals.

Author information

  • 1Department of Clinical Biochemistry, Fife Area Laboratories, Victoria Hospital, Kirkcaldy KY2 5AG, UK. rebecca.pattenden@faht.scot.nhs.uk

Abstract

BACKGROUND:

The purpose of this study was to compare The Binding Site serum free light chain assay on two analytical platforms; the Dade Behring BNII and the Olympus AU400. Reference intervals were subsequently established on each analyser.

METHODS:

In total, 112 serum samples routinely submitted to the laboratory for protein electrophoresis were used for the comparison study. Reference interval data was generated from 126 ostensibly healthy anonymous individuals.

RESULTS:

Serum free light chain results on the BNII and AU400 analysers are not directly comparable. The BNII produces results which are significantly higher than the AU400.

CONCLUSIONS:

Laboratories using The Binding Site serum free light chain assay are strongly advised to establish local reference intervals.

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PMID:
17961304
[PubMed - indexed for MEDLINE]
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