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Genome Biol. 2007;8(10):R229.

Simplified ontologies allowing comparison of developmental mammalian gene expression.

Author information

  • 1South African National Bioinformatics Institute, University of the Western Cape, Bellville 7535, South Africa. adele@sanbi.ac.za

Abstract

Model organisms represent an important resource for understanding the fundamental aspects of mammalian biology. Mapping of biological phenomena between model organisms is complex and if it is to be meaningful, a simplified representation can be a powerful means for comparison. The Developmental eVOC ontologies presented here are simplified orthogonal ontologies describing the temporal and spatial distribution of developmental human and mouse anatomy. We demonstrate the ontologies by identifying genes showing a bias for developmental brain expression in human and mouse.

PMID:
17961239
[PubMed - indexed for MEDLINE]
PMCID:
PMC2246303
Free PMC Article

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