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Simplified ontologies allowing comparison of developmental mammalian gene expression.
South African National Bioinformatics Institute, University of the Western Cape, Bellville 7535, South Africa. adele@sanbi.ac.za
Model organisms represent an important resource for understanding the fundamental aspects of mammalian biology. Mapping of biological phenomena between model organisms is complex and if it is to be meaningful, a simplified representation can be a powerful means for comparison. The Developmental eVOC ontologies presented here are simplified orthogonal ontologies describing the temporal and spatial distribution of developmental human and mouse anatomy. We demonstrate the ontologies by identifying genes showing a bias for developmental brain expression in human and mouse.
PMID: 17961239 [PubMed - indexed for MEDLINE]
PMCID: PMC2246303
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Cited by 2 PubMed Central articles
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Prioritizing genes of potential relevance to diseases affected by sex hormones: an example of myasthenia gravis.
Kaur M, Schmeier S, MacPherson CR, Hofmann O, Hide WA, Taylor S, Willcox N, Bajic VB.
BMC Genomics. 2008 Oct 13; 9:481. Epub 2008 Oct 13.
[BMC Genomics. 2008]
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Database for exploration of functional context of genes implicated in ovarian cancer.
Kaur M, Radovanovic A, Essack M, Schaefer U, Maqungo M, Kibler T, Schmeier S, Christoffels A, Narasimhan K, Choolani M, et al.
Nucleic Acids Res. 2009 Jan; 37(Database issue):D820-3. Epub 2008 Sep 12.
[Nucleic Acids Res. 2009]