Molecules. 2007 Aug 20;12(8):1964-72.

Targeted synthesis of 1-(4-hydroxyiminomethylpyridinium)-3-pyridiniumpropane dibromide--a new nerve agent reactivator.

Kuca K, Musilek K, Paar M, Jun D, Stodulka P, Hrabinova M, Marek J.

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Center of Advanced Studies, Faculty of Military Health Sciences, Hradec Kralove, Czech Republic.

Abstract

Preparation of 1-(4-hydroxy-iminomethylpyridinium)-3-pyridiniumpropane dibromide is described. This compound represents a new acetylcholinesterase (AChE) reactivator, which has no substituents on the second pyridinium ring as found in other commonly used AChE reactivators. The reactivation ability of this reactivator was tested on tabun- and cyclosarin-inhibited AChE. According to the results obtained, the new compound (without substitution and with decreased molecule size) showed increased reactivation potency in case of cyclosarin inhibited AChE. A potent oxime for treatment of tabun and cyclosarin-caused intoxications was thus obtained via slight modification of the reactivator structure (compared to trimedoxime and K027).

PMID:: 17960099; [PubMed - indexed for MEDLINE]

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Cited by 1 PubMed Central article

Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats. [Int J Mol Sci. 2009]
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