Biochem Soc Trans. 2007 Nov;35(Pt 5):1171-4.

Insulin action on the liver in vivo.

Cherrington AD, Moore MC, Sindelar DK, Edgerton DS.

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Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, 704 Robinson Research Bldg, Nashville, TN 37232-0615, U.S.A. alan.cherrington@vanderbilt.edu

Abstract

Insulin has a potent inhibitory effect on hepatic glucose production by direct action at hepatic receptors. The hormone also inhibits glucose production by suppressing both lipolysis in the fat cell and secretion of glucagon by the alpha-cell. Neural sensing of insulin levels appears to participate in control of hepatic glucose production in rodents, but a role for brain insulin sensing has not been documented in dogs or humans. The primary effect of insulin on the liver is its direct action.

PMID:: 17956305; [PubMed - indexed for MEDLINE]

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