Format

Send to

Choose Destination
See comment in PubMed Commons below
J Infect. 2007 Dec;55(6):488-94. Epub 2007 Oct 22.

Kawasaki-like syndromes in HIV-infected adults.

Author information

  • 1Department of Internal Medicine, Hôtel-Dieu, and University Claude Bernard, Lyon, France. katia.stankovic@libertysurf.fr

Abstract

BACKGROUND:

Kawasaki-like syndrome (KLS) is rare in adults; one third of these patients are infected by Human immunodeficiency virus (HIV). Our study reports cases of KLS occurring in HIV-positive adults and reviews the literature to compare their characteristics with HIV-negative adults and children with Kawasaki disease (KD).

METHODS:

Report of cases and review of the literature.

RESULTS:

Amongst 20 cases reviewed, including 4 who were managed at our institution, KLS was associated with severe immunosuppression and a high HIV viral load. There was frequent co-infection by hepatitis viruses. Desquamation and liver abnormalities were more frequent in HIV-negative adults whereas headaches and gastrointestinal disorders more common in HIV-positive adults. Intravenous immunoglobulin was effective therapy. Relapse was more frequent among HIV-positive patients. No cardiovascular complications or deaths occurred.

CONCLUSIONS:

Advanced immunosuppression due to HIV may predispose to KLS. The differential diagnosis that must be considered includes drug hypersensitivity reactions and staphylococcal infections.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk