Arch Dis Child Fetal Neonatal Ed. 2007 Nov;92(6):F498-502.

Patent ductus arteriosus: lack of evidence for common treatments.

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Carl L Bose, Division of Neonatal-Perinatal Medicine, CB#7596, UNC Hospital, Chapel Hill, NC 27599-7596, USA cbose@med.unc.edu

Abstract

Patent ductus arteriosus (PDA) is a common diagnosis among extremely premature infants, especially in those with lung disease. Treatments are often used to close the PDA. Despite nearly three decades of research, the question of whether the benefits of treatments to prevent ductal patency or promote closure outweigh the risks of these treatments remains unanswered. The authors rarely use treatments designed to close the PDA. This article reviews three considerations in support of this restrained approach: rates of spontaneous closure of the ductus arteriosus; adverse effect of persistent ductal patency; and benefits and risks of treatments for closure.

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Cyclooxygenase Inhibitors

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Cited by 5 PubMed Central articles

Treatment of patent ductus arteriosus with bidirectional flow in neonates. [Early Hum Dev. 2011]
Treatment of patent ductus arteriosus with bidirectional flow in neonates.
Ethington PN, Smith PB, Katakam L, Goldberg RN, Cotten CM. Early Hum Dev. 2011 May; 87(5):381-4. Epub 2011 Mar 12.
Role of prophylactic surgical ligation of patent ductus arteriosus in extremely low birth weight infants: Systematic review and implications for clinical practice. [Ann Pediatr Cardiol. 2009]
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Mosalli R, Alfaleh K, Paes B. Ann Pediatr Cardiol. 2009 Jul; 2(2):120-6.
Early surgical ligation versus a conservative approach for management of patent ductus arteriosus that fails to close after indomethacin treatment. [J Pediatr. 2010]
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