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Genetics. 2007 Nov;177(3):1851-8. Epub 2007 Oct 18.

Using crossover breakpoints in recombinant inbred lines to identify quantitative trait loci controlling the global recombination frequency.

Author information

  • 1Institute of Plant Genetics, Leibniz Universität Hannover, 30419 Hannover, Germany.

Abstract

Recombination is a crucial component of evolution and breeding, producing new genetic combinations on which selection can act. Rates of recombination vary tremendously, not only between species but also within species and for specific chromosomal segments. In this study, by examining recombination events captured in recombinant inbred mapping populations previously created for maize, wheat, Arabidopsis, and mouse, we demonstrate that substantial variation exists for genomewide crossover rates in both outcrossed and inbred plant and animal species. We also identify quantitative trait loci (QTL) that control this variation. The method that we developed and employed here holds promise for elucidating factors that regulate meiotic recombination and for creation of hyperrecombinogenic lines, which can help overcome limited recombination that hampers breeding progress.

PMID:
17947409
[PubMed - indexed for MEDLINE]
PMCID:
PMC2147985
Free PMC Article

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