Using quantitative imaging techniques to assess vascularity in AIDS-related Kaposi's sarcoma

Abby Vogel; Bahar Dasgeb; Moinuddin Hassan; Franck Amyot; Victor Chernomordik; Yang Tao; Stavros G Demos; Kathleen Wyvill; Karen Aleman; Richard Little; Robert Yarchoan; Amir H Gandjbakhche

doi:10.1109/IEMBS.2006.259462

Using quantitative imaging techniques to assess vascularity in AIDS-related Kaposi's sarcoma

Conf Proc IEEE Eng Med Biol Soc. 2006:2006:232-5. doi: 10.1109/IEMBS.2006.259462.

Authors

Abby Vogel¹, Bahar Dasgeb, Moinuddin Hassan, Franck Amyot, Victor Chernomordik, Yang Tao, Stavros G Demos, Kathleen Wyvill, Karen Aleman, Richard Little, Robert Yarchoan, Amir H Gandjbakhche

Affiliation

¹ Laboratory of Integrative & Medical Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. vogelab@mail.nih.gov

PMID: 17946806
DOI: 10.1109/IEMBS.2006.259462

Abstract

Three quantitative and non-invasive techniques were used to monitor angiogenesis in Kaposi's sarcoma patients: thermography, laser Doppler imaging (LDI), and near-infrared spectroscopy. Before and after combination cytotoxic and anti-angiogenesis therapy, blood volume, oxygenated hemoglobin, temperature, and blood flow were analyzed. These three techniques are objective, easy to perform, and appear to be very sensitive in assessing changes in the lesions upon administration of therapy.

Publication types

Evaluation Study

MeSH terms

Acquired Immunodeficiency Syndrome / diagnosis*
Humans
Image Interpretation, Computer-Assisted / methods
Laser-Doppler Flowmetry / methods*
Neovascularization, Pathologic / diagnosis*
Reproducibility of Results
Sarcoma, Kaposi / diagnosis*
Sensitivity and Specificity
Spectrophotometry, Infrared / methods*
Thermography / methods*