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    Conf Proc IEEE Eng Med Biol Soc. 2006;1:1838-41.

    Cell trapping in activated micropores for functional analysis.

    Talasaz AH, Powell AA, Stahl P, Ronaghi M, Jeffrey SS, Mindrinos M, Davis RW.

    Electr. Eng. Dept., Stanford Univ., CA 94305, USA. atalasaz@stanford.edu

    This paper presents a novel device which provides the opportunity to perform high-throughput biochemical assays on different individual cells. In particular, the proposed device is suited to screen the rare cells in biological samples for early stage cancer diagnosis and explore their biochemical functionality. In the process, single cells are precisely positioned and captured in activated micropores. To show the performance of the proposed device, cultured yeast cells and human epithelial circulating tumor cells are successfully captured.

    PMID: 17945673 [PubMed - indexed for MEDLINE]

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