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Metab Eng. 2008 Nov;10(6):305-11. Epub 2007 Sep 14.

Metabolic engineering of Escherichia coli for 1-butanol production.

Author information

  • 1Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA.

Abstract

Compared to ethanol, butanol offers many advantages as a substitute for gasoline because of higher energy content and higher hydrophobicity. Typically, 1-butanol is produced by Clostridium in a mixed-product fermentation. To facilitate strain improvement for specificity and productivity, we engineered a synthetic pathway in Escherichia coli and demonstrated the production of 1-butanol from this non-native user-friendly host. Alternative genes and competing pathway deletions were evaluated for 1-butanol production. Results show promise for using E. coli for 1-butanol production.

PMID:
17942358
[PubMed - indexed for MEDLINE]

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