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Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Jan;105(1):113-20. Epub 2007 Oct 17.

The role of dental pulp cells in resorption of deciduous teeth.

Author information

  • 1Department of Pediatric Dentistry, Faculty of Dentistry, Selcuk University, Konya, Turkey. ysibel@msn.com

Abstract

OBJECTIVE:

To address the question whether dental pulp cells of exfoliating human deciduous teeth have some roles for controlling or regulating the root resorption via secreting key molecules (OPG, RANKL, CSF-1, TGFbeta, MCP-1 and Cbfa-1) in osteoclastogenesis, we used a sensitive reverse transcriptase polymerase chain reaction (RT-PCR) method for detection of mRNA expressions for the cytokines listed.

STUDY DESIGN:

The dental pulps were retrieved from incisor and molar teeth in the late stage of shedding (n = 30) and from sound premolar teeth extracted for orthodontic reasons (control group; n = 30). The RT-PCR assays were used to identify targeted gene expression.

RESULTS:

Of the cytokines examined, RANKL and CSF-1 expressions showed significantly higher occurrence in deciduous dental pulps than in permanent teeth pulpal tissues (P < .040).

CONCLUSIONS:

The findings may suggest an interactive role for pulp tissue cells in the physiologic root resorption process. The cells of dental pulp may have some cytokine-producing cells which mediate monocyte-macrophage lineage to form osteo/odontoclasts, and the RANKL/RANK system might be involved in human deciduous teeth resorption.

PMID:
17942342
[PubMed - indexed for MEDLINE]
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