[Dubowitz syndrome. A diagnosis not to be missed]

Centre de Génétique, CHU Nord, Amiens.

Dubowitz syndrome is a rare hereditary disorder whose main features are intra-uterine and post-natal growth retardation, characteristic facies, microcephaly, mental retardation and poor feeding. Because of the eczema which was present in half of the cases after 4 years of age, it cannot be mistaken for the more frequent fetal alcohol syndrome. We report 5 cases, among whom two sibs, confirming the recessive autosomal mode of inheritance and the necessity for genetic counseling.

PMID: 1793348 [PubMed - indexed for MEDLINE]