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Expert Rev Vaccines. 2007 Oct;6(5):699-710.

MF59 is a safe and potent vaccine adjuvant that enhances protection against influenza virus infection.

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  • 1Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy. derek.ohagan@novartis.com

Abstract

In preclinical studies, MF59 adjuvant offered improved protection against influenza virus challenge and significantly reduced the viral load in the lungs of challenged mice. In humans, MF59 is a safe and potent vaccine adjuvant that has been licensed in more than 20 countries (Fluad [Novartis Vaccines and Diagnostics Inc., MA, USA]). The safety profile of an MF59-adjuvanted vaccine is well established through a large safety database. MF59 adjuvant has had a significant impact on the immunogenicity of influenza vaccines in the elderly and in adults who are chronically ill. MF59 has also been shown to have a significant impact on the immunogenicity of pandemic influenza vaccines. MF59 allows for broader cross-reactivity against viral strains not included in the vaccine. MF59 has been shown to be more potent for both antibody and T-cell responses than aluminum-based adjuvants. MF59 has broad potential to be used as a safe and effective vaccine adjuvant for a wide range of vaccine types.

PMID:
17931151
[PubMed - indexed for MEDLINE]
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