Concomitant Creutzfeldt-Jakob and Alzheimer diseases

J M Powers; Y Liu; L S Hair; R J Kascsack; L D Lewis; L A Levy

doi:10.1007/BF00294437

Concomitant Creutzfeldt-Jakob and Alzheimer diseases

Acta Neuropathol. 1991;83(1):95-8. doi: 10.1007/BF00294437.

Authors

J M Powers¹, Y Liu, L S Hair, R J Kascsack, L D Lewis, L A Levy

Affiliation

¹ Department of Pathology, Columbia-Presbyterian Medical Center, New York, NY.

PMID: 1792870
DOI: 10.1007/BF00294437

Abstract

We report a 69-year-old female with cerebral and cerebellar symptomatology of 15-month duration. At autopsy, both panencephalopathic Creutzfeldt-Jakob and plaque-predominant Alzheimer diseases were found. Plaque amyloid was exclusively of the beta/A4 type, but abundant abnormal protease-resistant protein was identified by Western blot analysis of brain extracts.

Publication types

Case Reports

MeSH terms

Aged
Alzheimer Disease / complications
Alzheimer Disease / diagnostic imaging
Alzheimer Disease / pathology*
Amyloid beta-Peptides / metabolism
Atrophy / pathology
Blotting, Western
Brain / diagnostic imaging
Brain / pathology
Brain Chemistry
Creutzfeldt-Jakob Syndrome / complications
Creutzfeldt-Jakob Syndrome / diagnostic imaging
Creutzfeldt-Jakob Syndrome / pathology*
Female
Humans
Immunoenzyme Techniques
Tomography, X-Ray Computed

Substances

Amyloid beta-Peptides