Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Physiology (Bethesda). 2007 Oct;22:303-9.

Phospho-regulation of Beta-catenin adhesion and signaling functions.

Author information

  • 1The Integrated Graduate Program in the Life Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. c-gottardi@northwestern.edu

Abstract

Beta-catenin plays a critical structural role in cadherin-based adhesions and is also an essential co-activator of Wnt-mediated gene expression. The degree to which beta-catenin participates in these two functions is dictated by the availability of beta-catenin binding partners, and an emerging theme is that these binding interactions are regulated by phosphorylation. Inputs from various cell-signaling events can therefore impact beta-catenin function, which may be necessary for the finely tuned adhesive and signaling responses required for tissue morphogenesis.

PMID:
17928543
[PubMed - indexed for MEDLINE]
PMCID:
PMC2276853
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk