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PLoS One. 2007 Oct 10;2(10):e1007.

Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT.

Author information

  • 1The Howard Hughes Medical Institute, The Ludwig Center for Cancer Genetics and Therapeutics at Johns Hopkins, Baltimore, Maryland, United States of America.

Abstract

BACKGROUND:

Traditional imaging techniques for the localization and monitoring of bacterial infections, although reasonably sensitive, suffer from a lack of specificity. This is particularly true for musculoskeletal infections. Bacteria possess a thymidine kinase (TK) whose substrate specificity is distinct from that of the major human TK. The substrate specificity difference has been exploited to develop a new imaging technique that can detect the presence of viable bacteria.

METHODOLOGY/PRINCIPAL FINDINGS:

Eight subjects with suspected musculoskeletal infections and one healthy control were studied by a combination of [(124)I]FIAU-positron emission tomography and CT ([(124)I]FIAU-PET/CT). All patients with proven musculoskeletal infections demonstrated positive [(124)I]FIAU-PET/CT signals in the sites of concern at two hours after radiopharmaceutical administration. No adverse reactions with FIAU were observed.

CONCLUSIONS/SIGNIFICANCE:

[(124)I]FIAU-PET/CT is a promising new method for imaging bacterial infections.

PMID:
17925855
[PubMed - indexed for MEDLINE]
PMCID:
PMC1994593
Free PMC Article

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